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1400W dihydrochloride

CAS No. 214358-33-5

1400W dihydrochloride ( —— )

产品货号. M13428 CAS No. 214358-33-5

1400 W 是一种高效、选择性的诱导型 NOS2 (iNOS) 抑制剂。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥348 有现货
10MG ¥551 有现货
25MG ¥1029 有现货
50MG ¥1871 有现货
100MG ¥3183 有现货
200MG ¥4139 有现货
500MG ¥6715 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    1400W dihydrochloride
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    1400 W 是一种高效、选择性的诱导型 NOS2 (iNOS) 抑制剂。
  • 产品描述
    1400 W is a highly potent and selective inhibitor of inducible NOS2 (iNOS).
  • 体外实验
    1400W is a slow, tight binding inhibitor of human inducible nitric- oxide synthase (iNOS). The slow onset of inhibition by 1400W shows saturation kinetics with a maximal rate constant of 0.028 s-1 and a binding constant of 2.0 μM. Inhibition is dependent on the cofactor NADPH. 1400W is at least 5000-fold selective for iNOS versus eNOS. In contrast, inhibition of human neuronal NOS and endothelial NOS (eNOS) is relatively weaker, rapidly reversible, and competitive with L-arginine, with Ki values of 2 μM and 50 μM, respectively. 1400W treatment inhibits iNOS expression without affecting nNOS or eNOS. 1400W also reduces NO, 3-NT and MDA production, and prevents neuronal cell apoptosis in cerebral cortex.
  • 体内实验
    1400W potently (ED50=0.3 mg/kg) reduces the delayed vascular injury in rats attributable to LPS-induced iNOS but fails to exacerbate acute vascular leakage when given concurrently with LPS. Administration of 1400W lowers NOx levels in all the experimental groups. In addition, lipid peroxidation, the percentage of apoptotic cells, and nitrated protein expression fall in the late post-hypoxia period (48 h and 5 days).
  • 同义词
    ——
  • 通路
    Immunology/Inflammation
  • 靶点
    NOS
  • 受体
    eNOS| iNOS| nNOS
  • 研究领域
    Other Indications
  • 适应症
    ——

化学信息

  • CAS Number
    214358-33-5
  • 分子量
    213.709
  • 分子式
    C10H16ClN3
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO:0.25 mg/ml; DMF :0.25 mg/ml; Ethanol :0.25 mg/ml: Water :100 mM
  • SMILES
    CC(=NCC1=CC(=CC=C1)CN)N.Cl.Cl
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Thomsen LL1, Scott JM, Topley P, Knowles RG, Keerie AJ, Frend AJ.Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor.Cancer Res. 1997 Aug 1;57(15):3300-4.
产品手册
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